Arlene Francis (born Arline Francis Kazanjian; October 20, 1907 – May 31, 2001) was an American game show panelist, actress, radio and television talk show host. She is best known for her long-running role as a panelist on the television game show What's My Line?, on which she regularly appeared for 25 years, from 1950 to 1975, on both the network and syndicated versions of the show.

Francis became a well-known New York City radio personality, hosting several programs. In 1938 she became the female host of the radio game show What's My Name? Although several men appeared as co-hosts over the years, Francis was the sole female host throughout the program's long run (on ABC, NBC, and Mutual networks) until it ended in 1949. In 1940, Francis played Betty in Betty and Bob, an early radio soap opera broadcast. In 1943, she began as host of a network radio game show, Blind Date, which she hosted also on ABC and NBC television from 1949 to 1952 From 1952 to 1961 she was a regular substitute for Dave Garroway on the Today Show. She was a regular contributor to NBC Radio's Monitor in the 1950s and 1960s and hosted a long-running midday chat show on WOR-AM that ran from 1960 to 1984.